Successful Management of Pregnancy and Cesarean Section in a Patient with a Qualitative Variant of Glanzmann Thrombasthenia

A 19-year-old woman with a qualitative variant of Glanzmann Thrombasthenia (GT) was referred to our department for her first pregnancy. The diagnosis of GT was revealed by epistaxis and gingival bleeding. Her history of bleeding was limited to dental procedures and haemorrhagic rupture of an ovarian cyst under platelet transfusion. Her husband had normal platelet function tests and no consanguinity was suspected. No antiGPIIb-IIIa and anti-HLA antibodies were detected before the pregnancy. No bleeding occurred during the pregnancy. At 38 weeks, the membranes ruptured. A first concentrate of platelets was transfused and labour was induced by ocytocin. It failed, and a C-section was performed. A second concentrate of platelets was administered just before the incision; recombinant activated factor VII (rFVIIa) was available but not used. Post-partum haemorrhage (PPH) did not occur.